The hand as a sign-post to ocular disease. V.

Genodermatoses Ichthyosis This hereditary condition is characterized by hyperkeratosis or hypertrophy of the horny layers of the skin which is dry and scaly and looks dirty (Fig. 1). Besides dominant, autosomal recessive, and sex-linked recessive forms, ichthyosis also occurs in the SjogrenLarsson syndrome (ichthyosis, spasticity, and oligophrenia) and in Refsum's syndrome, a disturbance of lipid metabolism (ichthyosis, atypical retinitis pigmentosa, polyneuritis, and deafness). Blepharitis is common in ichthyosis and may